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Results 1 - 40 of 145
Characterization of Therapeutic Oligonucleotides by NMR at 1 GHz and 600 MHz
Therapeutic oligonucleotides (ONs) are a new class of molecules that hold great promises to treat pathologies that cannot be cured with classical therapies. Their accurate characterization is critical for both the pharmaceutical industry and regulatory agencies.
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Towards advanced continuous manufacturing with Bruker’s Fourier PAT
Nuclear magnetic resonance (NMR) spectroscopy’s powerful insights can be leveraged to improve advanced (bio) pharmaceutical manufacturing operations, such as continuous flow chemistry. This is now easier, thanks to the latest benchtop solutions.
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EPR for Energy: Conversion and Storage
Energy systems across the globe are undergoing a fundamental transformation. As we continue to decrease dependence on fossil fuels, the world is demanding more diverse power solutions for our energy needs. Batteries convert chemical energy to electrical energy, with all or most of the reactants stored within the battery.
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One-Step Contactless Check Weighing with TD-NMR
Contactless Check Weighing is traditionally a two-step process, but TD-NMR technology offers a much more convenient one-step solution. Learn more here.
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NMR is an Essential Tool for the Identification and Characterization of Novel, Illicit Opioids
Pain affects every individual at some point in their life and if this pain is persistent or severe, it can significantly impair mental and physical health as well as the quality of life. In 1995, to improve care, the American Pain Society declared that pain should be treated as the ‘fifth vital sign’. However, unlike the other four vital signs – body temperature, pulse rate, respiration rate and blood pressure – pain is subjective, making effective treatment difficult. Despite the good intention...
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NMR-Based Quantification of Liquid Products in CO
2
Electroreduction on Phosphate-Derived Nickel Catalysts
One of the biggest challenges in modern chemistry is finding ways to make the industrial-scale electrochemical reduction of CO
2
both economically and energetically viable.
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Battery research probes for Li-ion technologies (and beyond)
Discover how in situ solid-state nuclear magnetic resonance (NMR) spectroscopy is advancing battery research and development in our latest application note. Bruker's cutting-edge RF generation console AVANCE NEO, together with ePROBE's specialized probes and accessories, provide subject matter experts with the tools they need to research advanced and sustainable battery technology as the world strives to transition to renewable energy sources.
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Electron Paramagnetic Resonance for Quantum Information Science
Quantum computing promises to expand the frontiers of modern science by opening the doors to calculations practically impossible for classical computers. Quantum technology is made possible by the quantum bit (qubit), which takes advantage of the superposition of a two-level system, such as an electron or nucleus.
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Emulsions in the Petrochemical Industry
Bruker’s versatile and easy-to-use bench-top TD-NMR analyzer is a turn-key solution to measure unimodal droplet size distributions.
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Benchtop NMR as a Versatile Tool for Quality Control: Example of Poloxamer Compendial Testing
Learn more about the control challenges of polymeric materials used in pharmaceuticals and how these can be addressed by benchtop NMR. Focusing on alcohol ethoxylates for pharmaceutical applications, this whitepaper demonstrates the effectiveness of benchtop NMR for streamlined quantitative compendial testing and how the procedures can easily be extended to other products using the modern concept of platform procedures. The application of such techniques in quality control (QC) laboratories can ...
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Streamlining Identification Testing for Quality Control Using Benchtop NMR
Discover the benefits of using benchtop NMR on fluorinated active pharmaceutical ingredient.
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Streamlining Compendial Procedures with Benchtop NMR: Example of the USP-NF and Ph. Eur. Betadex Testing
Discover how benchtop NMR ensures cost-efficient testing of poloxamer for regulatory compliance.
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Compendial Identification Using Benchtop NMR: Example of Tobramycin According to Ph. Eur. 0645
Discover how benchtop NMR can be used as a robust, flexible and cost-efficient tool for hydroxypropyl betadex testing.
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Developing the Next Generation of Lithium Ion Battery
With their high energy density, light weight and deep charge cycles, Lithium ion batteries are a mainstay of modern portable electronic devices.
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Quantitative Assays with Fourier 80 Benchtop NMR: Benefits and Examples
Discover how benchtop NMR can streamline quantitative assays of drug substances and drug products.
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Benchtop NMR as a Versatile Tool for Quality Control: Example of Poloxamer Compendial Testing
Discover how benchtop NMR allow to increase confidence in identity testing.
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Benefits of using Benchtop NMR for Simplified Design & Risk-assessment of Analytical QC Procedures
Discover how benchtop NMR can streamline quality control analytical procedure development while ensuring very high robustness and flexibility.
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Assays for Fluorinated API Using the Fourier 80 Benchtop NMR
Discover the benefits of using benchtop NMR on fluorinated active pharmaceutical ingredient.
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Uncovering renewable sources for lithium batteries
The lithium-ion battery provides high-performance energy storage, enabling energy to be efficiently stored and delivered on demand. It is this type of battery that is widely used for the rechargeable batteries of portable electronic devices, such as mobile phones1. The reliable efficacy demonstrated by lithium-ion batteries as effective energy storage devices has resulted in this becoming the battery type of choice to power electric cars2. With the marked increase in electric car production to a...
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Multi-Nuclear In-Situ Pulsed Gradient Spin Echo (PGSE) NMR Observation of Ion Mobility in Ionic Liquids Used in Battery Technology
Lithium-ion batteries are currently the most energy-dense and therefore the most sought after. However, due to the limited availability of lithium, interest in sodium-based batteries is also growing. PGSE NMR provides unique opportunities to study such materials.
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High-Resolution Multi-Nuclear NMR Spectroscopy for Better Lithium-ion Battery Electrolytes
The conducting salt, which is the most valuable part of the electrolyte, is the core of LiBs. The electrolyte’s aging affects the chemistry of other essential elements like electrodes and their interfaces.
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Using EPR for Analysis of Metallic Lithium Microstructure
Besides NMR, EPR is particularly suited to detecting the desired structural change within a Metallic Lithium Microstructure. Click here to discover how researchers used in-situ EPRI to study lithium plating and stripping in anode-free LIBs, revealing the semiquantitative distribution and microstructural dimensions of Li deposits.
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Sensitive Detection of Electrodes' Surface Chemistry by MAS-DNP
A major challenge in the development of new high energy and high power rechargeable batteries is control over the interactions and parasitic reactions between the various battery cell components.
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Quantifying Ionic Conductivity and Cation Transfer Coefficient in Lithium-ion Battery Electrolytes by Diffusion Ordered NMR Spectroscopy
To increase the performance of batteries, it is critical to be able to characterize the mobility of ions in the electrolyte. Due to the chemical nature of the electrolytes’ components, multi-nuclear NMR spectroscopy can be used to gain insight, quantify, and understand changes in the electrical conductivity of the electrolyte.
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Multi-Modal Characterization and Analysis of Organic Redox-Flow Batteries by EPR and NMR
Researchers worldwide collaborate to discover new resources for sustainable energy. They investigate novel battery materials and systems for enhanced energy conversion efficiency and environmental friendliness.
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Analyzing electrode slurries to optimize cost of lithium-ion battery production using the Bruker minispec
Here we describe how the Bruker minispec Time Domain NMR (TD-NMR) spectrometer can measure critical physical properties of a slurry and allows manufacturers to optimize the coating process for lithium-ion batteries.
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Structure Elucidation | CMC-se
Structure Elucidation of small organic molecules is a key competence of NMR. In this video, we present Bruker’s Structure Elucidation suite “CMC-se”.
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Heating of Blood Samples to Deactivate SARS-CoV-2 Virus Can Lead to Incorrect Biomarker Identification
1H-NMR metabolic profiling using the IVDr platform enables to provide recommendations for Analytical Artefact Minimization with Special Reference to COVID-19/SARS-CoV-2 Plasma Samples
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Fragment Screening by Ligand Observed NMR
Ligand observed NMR is one of the most popular techniques used in Fragment Based Drug Discovery (FBDD).
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Assessing the Prevalence of Environmentally Persistent Free Radicals in Soil
EPFRs are not confined to combustion-generated particulate matter and are more widely present in the environment than originally suspected
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EPR Dosimetry Using Camel Enamel
EPR Dosimetry can be used for retrospective dose assessment of humans even without human teeth, Camel Enamel is available. Learn more here.
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Establishing The Purity of Nutraceuticals and Energy Drinks with NMR
Establishing the purity of nutraceuticals and energy drinks with NMR
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Resonance and Atomic Force Microscopy to Elucidate Oxidative Stress in Eye Disorders
Oxidative damage is thought to underlie many age-related disorders of the eye, and can be caused by oxidative molecules as well as photooxidation from UV light. The risk of AMD increases with exposure to light, highlighting the detrimental potential of oxidation to the aging eye.
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Chelating Agent Allows Regulation of Iron-Based Cancer Treatment to Reduce Toxicity
Heavy Metal in the Treatment of Cancer
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Evaluation of the Antioxidant Activity of Instant Coffee using ESR
Instant coffee has a radical scavenging activity of about 20 times that of blueberries
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Learning with the microESR: Giving Students Hands-on Experience
Electron paramagnetic resonance (EPR) spectroscopy is a powerful imaging technique (with a sensitivity up to 1000 times greater than NMR) that detects atoms and molecules containing unpaired electrons (i.e. they are paramagnetic).
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Fragment-based Screening Experiments in TopSpin
In a recent application note, Bruker applications scientist Donna Baldisseri outlines how to use TopSpin software for fragment-based screening.
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Low Levels of Superoxide Dismutase used for Free Radical Protection in Yeast
Our results will have implications for understanding the basic redox biology of SOD1 and better inform the treatment of diseases in which SOD1 or redox homeostasis can be targeted
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EPR Reveals Structural Changes in Alpha-Synuclein During Parkinson’s Disease
Electron paramagnetic resonance (EPR) spectroscopy is a highly suitable spectroscopy technique to investigate dynamics and conformations of aS [alpha synuclein]
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Evaluation of the Thermal Stability of New Polyamide Polymers
Within the next 50 years, the availability of crude oil is likely to be insufficient to meet the world’s ever-increasing energy needs.
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